Prof. Eunice Sindhuvi M.Sc., Ph.D
Professor
Christian Medical College Vellore
Bio / Career Interests
My research interests center on haemoglobinopathies and iron biology, with a long-standing focus on understanding the molecular mechanisms underlying hematological disorders. I began my research journey with haemoglobinopathies and completed my PhD on the molecular genetics of HbE, exploring genotype–phenotype correlations, identifying novel genetic variants, and investigating the transcriptional and translational regulation of HbE. This work gradually expanded into the field of iron metabolism, where I have studied the genetic determinants of iron absorption and handling, mechanisms of fetomaternal iron transfer during maternal iron deficiency, and the role of iron in secondary hemochromatosis. My current interests also include understanding how iron regulates the transcriptional switch between erythropoiesis and megakaryopoiesis, as well as the impact of iron overload on hematopoietic stem cells. More recently, I have extended my research into bone marrow failure syndromes, particularly aplastic anemia, focusing on the contribution of telomere length and genetic variants to disease pathogenesis. I am also interested in elucidating the mechanisms of androgen action in aplastic anemia and understanding why only a subset of patients respond to androgen therapy.